【摘要】 目的探讨大肠癌组织中转移相关因子与核因子κB(NF-κB)的表达特点及相互关系。方法用Western blot法检测大肠癌及正常组织中NF-κB、环氧合酶-2(COX-2)、细胞间黏附分子-1(ICAM-1)、血管细胞黏附分子-1(VCAM-1)以及基质金属蛋白酶-9(MMP-9)的表达。结果(1)大肠癌组织中,NF-κB活性升高(P<0.05);(2)在NF-κB表达升高的肿瘤组织中,COX-2、ICAM-1和VCAM-1表达升高的比例约占75%。(3)大肠癌组织中MMP-9与其抑制蛋白SM22α的表达呈负相关。结论大肠癌组织中转移相关因子的表达与NF-κB活性呈正相关,与肿瘤的进展和转移密切相关。更多还原

【Abstract】 Objective To investigate the relationship between NF-κB activation and the expression of metastasis correlation factors.Methods The expression of NF-κB,COX-2,ICAM-1,VCAM-1 and MMP9 in colorectal cancer and normal tissues was detected using Western blotting.Results(1)The expression level of NF-κB was higher in cancer tissues than that in normal tissues(P<0.05).(2)The expression of COX-2,ICAM-1 and VCAM-1 was higher in 75% cancer tissues,in which NF-κB was highly expressed.(3)MMP-9 expression was negatively correlated with its profilin SM22α.Conclusion The expression of metastasis correlation factors was positively related with the activation of NF-κB,and was responsible for the progression of colorectal carcinoma and for poor prognosis.更多还原