【摘要】 目的明确降钙素基因相关肽(CGRP)在先天性胫骨假关节(CPT)病变组织中的表达,以进一步研究CPT的病因及发病机制。方法取CPT患儿病变骨膜及假关节处骨质标本作为实验组,以正常骨膜、骨组织作为对照组,采用免疫组化方法对两组标本中CGRP的表达进行检测。结果CGRP主要位于骨膜的血管壁内和成骨细胞、破骨细胞胞质内,在CPT的骨膜和骨细胞中较对照组表达显著减弱。结论CGRP在CPT中表达减弱可能是导致先天性胫骨假关节的因素之一。更多还原

【Abstract】 Objective To examine the expression of CGRP in congenital pseudarthrosis of tibia(CPT) in order to find the pathogenesis of CPT.Methods Periosteum and bones from CPT patients were collected as experimental group.Immunohistochemistry stain was applied to determine the differences of the expression of CGRP in two groups.Results CGRP was located at vessel wall of periosteum and intracytoplasm of osteoblasts and osteoclasts in bones,its expression was significantly less in periosteum and bones of CPT than that in control group(P<0.05).Conclusion Anormaly expression of CGRP in CPT might be one of the causes of CPT.更多还原