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Synthesis of an AIE-active fluorogen and its application in cell imaging

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【作者】 LAM Jacky Wing Yip； FAISAL Mahtab； NG Ka Ming； LUO Kathy Qian；

【Author】 YU Yong1,2, HONG YuNing1, FENG Chao3, LIU JianZhao1, LAM Jacky Wing Yip1, FAISAL Mahtab1, NG Ka Ming2, LUO Kathy Qian2,3 & TANG Ben Zhong1,3,4 1 Department of Chemistry, The Hong Kong University of Science & Technology (HKUST), Clear Water Bay, Hong Kong, China; 2 Department of Chemical and Biomolecular Engineering, HKUST, Clear Water Bay, Kowloon, Hong Kong, China; 3 Bioengineering Graduate Program, HKUST, Clear Water Bay, Kowloon, Hong Kong, China; 4 Institute of Biological and Medical Macromolecules, Zhejiang University, Hangzhou 310027, China

【机构】 Department of Chemistry, The Hong Kong University of Science & Technology (HKUST), Clear Water Bay； Department of Chemical and Biomolecular Engineering, HKUST, Clear Water Bay； Bioengineering Graduate Program, HKUST, Clear Water Bay；

【摘要】 A fluorogen named 1-decyl-1-methyl-2,5-bis{4-[(N,N-diethylamino)methyl]phenyl}-3,4-diphenylsilole (3) was synthesized. It emitted weakly as isolated molecule but strongly as supramolecular aggregate, showing a characteristic behavior of aggregation-induced emission (AIE). The molecules of 3 formed highly emissive nanoparticles in aqueous media, which quickly and selectively marked cytoplasm of HeLa cells and posed no toxicity to the living cells. The fluorogen is thus a promising candidate mate-rial for cell imaging as a sensitive, selective and cytocompatible biosensor.更多还原

【Abstract】 A fluorogen named 1-decyl-1-methyl-2,5-bis{4-[(N,N-diethylamino)methyl]phenyl}-3,4-diphenylsilole (3) was synthesized. It emitted weakly as isolated molecule but strongly as supramolecular aggregate, showing a characteristic behavior of aggregation-induced emission (AIE). The molecules of 3 formed highly emissive nanoparticles in aqueous media, which quickly and selectively marked cytoplasm of HeLa cells and posed no toxicity to the living cells. The fluorogen is thus a promising candidate mate-rial for cell imaging as a sensitive, selective and cytocompatible biosensor.更多还原

【关键词】 aggregation-induced emission； biosensor； cell imaging；
【Key words】 aggregation-induced emission； biosensor； cell imaging；

【基金】 Supported by the Research Grants Council of Hong Kong (Grant Nos. 603008, 601608 and 602707);the National Natural Science Foundation of China (Grant No. 20634020);the CAO GuangBiao Foundation of Zhejiang University

【文献出处】 Science in China(Series B:Chemistry) ,中国科学(B辑:化学)(英文版) , 编辑部邮箱 ,2009年01期

【分类号】O621.2
【被引频次】26
【下载频次】197

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