【摘要】 目的了解辽宁省流行性脑脊髓膜炎(流脑)菌群变化和人群抗体水平。方法流脑菌培养、鉴定用巧克力培养基于(36±0.5)℃、5%CO2培养;用ELISA法检测抗体。结果8个年龄组901份血清样本检测结果表明,辽宁省的流脑病例多数由流脑A群引起,也有流脑C群病例存在,病例接触者携带流脑菌以A群为主,占72%。人群抗体水平A群抗体保护率为76.25%,平均抗体含量为11.78μg/ml。C群抗体保护率为53.39%,平均抗体含量为3.73μg/ml。A群C群间抗体水平差异有统计学意义。各年龄组间抗体水平差异有统计学意义。结论辽宁省流脑发病仍以婴幼儿为主,有向大年龄组迁移趋势,存在菌群变异可能,人群抗体水平不足以阻止C群流脑流行,需加强人群免疫,加强疾病监测,采取措施,保护人群健康。更多还原

【Abstract】 Objective To determine the flora of epidemic cerebrospinal meningitis(ECM) and human antibody levels against ECM in Liaoning province.Methods ECM bacteria were cultured and identified on chocolate agar plates under(36 ± 0.5) ℃ with 5% CO2,antibodies detected by ELISA.Results In Liaoning province,most meningitis cases were caused by group A meningococci,and the rest group C.Group A meningococci were primarily detected among carriers,accounting for 72%.The protective rate of antibodies against group A meningococci was 76.25%,the mean antibody content 11.78 μg/ml.The protective rate of Group C antibodies was 53.39%,the mean antibody content 3.73 μg/ml.Great differences were noticed in between Group A and C antibody levels.Significant differences were found in the antibody levels between age groups.Conclusion Infants and children were primarily affected by meningitis in Liaoning province.However,the susceptible age is increasing,suggesting potential flora variation.Since current human antibody levels are not sufficient to prevent the epidemic of group C meningitis,is it necessary to strengthen the immunity in general population and improve disease surveillance and countermeasures to prevent and control ECM epidemic.更多还原