【摘要】 目的探讨应用小剂量螺内酯干预急性心肌梗死(AMI)患者左室重构(LVRM)的影响。方法80例AMI患者,采用随机、对照方法,分为对照组(n=38)常规治疗,螺内酯组(n=42)在常规治疗的基础上加用螺内酯40mg/d。在治疗6个月内检测2组患者血清Ⅲ型前胶原氨基端肽(PⅢNP)、血清透明质酸(HA)及心脏核磁共振,以评价左室纤维化和左室功能。结果治疗6个月后,螺内酯组PⅢNP、HA较对照组明显下降(P<0.01),左室收缩末期内径与对照组相比明显下降,LVEF明显升高,延迟强化灶体积明显下降(P<0.05)。结论常规治疗的基础上联合应用小剂量螺内酯,可进一步抑制左室重构、改善心功能。更多还原

【Abstract】 Objective To investigate the effect of spironolactone on left ventricular remodeling(LVRM) in patients with acute myocardial infarction.Methods In this randomized,controlled study, 80 AMI patients were divided into routine treatment group(n=38) and spironolactone intervention group(n=42).Spironolactone 40mg/d was administered in addition to the routine treatment for patients of spironolactone intervention group.During the 6 months,the serum PⅢ NP,HA and MRI were examined in all patients to assess myocardial fibrosis and LV function.Results After 6-month intervention,P Ⅲ NP and HA serum levels were significantly lower in the spironolactone intervention group(P<0.01);the spironolactone intervention group had a lower LVESD and delayed enhancement volume, had a higher LVEF compared with controlled group(P<0.05). Conclusion In patients with AMI,spironolactone combined with the routine treatment could inhibit LVRM and and improve LV function.更多还原