【摘要】 目的探讨急性脑梗死治疗前后血浆同型半胱氨酸(homocysteine,Hcy)水平变化的临床意义。方法动态监测97例急性脑梗死病例在临床治疗前后血浆同型半胱氨酸变化情况并与正常对照组进行比较分析。结果脑梗3组病人入院时血Hcy水平比对照组有明显升高,差异有显著性意义,治疗后1周及2周后血Hcy有降低趋势,但3组间差异无显著性意义,8例因病情加重出院患者,第1周血Hcy有明显增高。结论高Hcy血症与急性脑梗死关系密切,经有效治疗后血清Hcy有降低趋势,提示血清Hcy水平变化可为急性脑梗死的疗效观察及其预后的判断提供新的依据。更多还原

【Abstract】 Objective The current study was designed to observe the changes of homocysteine before and after treatment of acute cerebral infarction,judging the worth of homocysteine in clinical treatment.Methods The levels of plasma homocysteine from 97 acute cerebral infarction patients and 80 healthy subjects were measured.Results The level of plasma homocysteine was significantly higher than that in acute cerebral infarction group compared with that in control group on admission.There were significant differences of statistics between two groups(P<0.05).Comparing prior treatment there were downtrend according to monitoring results of homocysteine at 7 days and 14 days on post-treatment,though there were not significant differences of statistics among three groups. Obviously increase of homocysteine was emerged in eight aggravating cases that didn’t accomplish the course of treatment.Conclusion Hyperhomocysteinemia has closely relationship to acute cerebral infarction and could be a risk factor to cerebral infarction.Dynamic measuring the level of homocysteine could make for evaluating curative effects of acute cerebral infarction.更多还原