【摘要】 目的研究7-烷氧白杨素衍生物的体外抗癌活性。方法合成7-烷氧取代的白杨素衍生物,并通过MTT法检测其对人急性粒细胞性白血病(HL-60)细胞、人结肠癌(HT-29)细胞和人胃癌(SGC-7901)细胞增殖抑制作用。结果合成了6个烷氧取代白杨素衍生物,其中化合物2b对HT-29细胞增殖的抑制作用强于5-Fu;化合物2a、2b、2e、2d对HL-60细胞增殖的抑制作用强于5-Fu。结论7-烷氧白杨素衍生物具有潜在的抗癌活性。更多还原

【Abstract】 Objective To study the anticancer activity of 7-alkoxy chrysin derivatives. Methods 7-Alkoxy chrysin derivatives were prepared and their anticancer activities in vitro were evaluated by the standard MTT method. Results Compound 2b showed more stronger activity against HT-29 cells than 5-Fu,and compound 2a,2b,2e,2d had stronger activity against HL-60 cells than 5-Fu. Conclusion 7-Alkoxy chrysin derivatives possessed the potent anticancer activity.更多还原