【摘要】 目的:观察阿霉素持续静脉输注联合国产长春瑞滨(盖诺NVB)治疗晚期乳腺癌的疗效及毒副反应,探讨治疗方式改变在化疗中的价值。方法:32例晚期乳腺癌患者,用NA方案:NVB 25 mg/m2ivgtt d1,8、ADM 50 mg/m2civ 96h d1~4。每28天为一周期,至少2周期后评价疗效。观察疗效及毒副反应。结果:32例患者均随访。总共用药170周期,平均5.3周期。CR 5例,PR 18例,RR(CR+PR)71.9%。初治、复治有效率分别为73.3%、70.6%,二者间无显著性差异(P>0.05)。中位缓解期8.2个月。主要毒副反应为白细胞降低,发生率100%(32/32),32例中Ⅲ~Ⅳ度下降15例(46.9%);恶心、呕吐23例(71.9%),Ⅲ~Ⅳ度4例(12.5%);均发生脱发,Ⅲ~Ⅳ度5例(15.6%);口腔炎16例(50.0%),Ⅲ~Ⅳ度4例(12.5%);静脉炎2例(6.2%),均为Ⅰ度;心脏毒性发生3例(9.4%),为Ⅰ、Ⅱ度不等。无治疗相关性死亡。结论:阿霉素持续静脉输注与盖诺联合治疗晚期转移性乳腺癌疗效明确,毒副反应可以耐受,远期疗效值得进一步研究。更多还原

【Abstract】 Objective:To investigate the efficacy of combined chemotherapy based on NA,ADM as a 96h continous intravenous infusion on breast cancer,and its side-effects.Methods:NA scheme was formed with ADM constant intervenous injection in 50mg/m2 for 96h in 32 patients with metastatic breast cancer with 28 days as one cycle,after at least 2 cycles of treatment.The therapeutic efficacy and clinical symptoms were evaluated.Results:The overall response rate for the whole group of patients was 71.9%.The primary group obtained effective rate by 73.3%,relapse group by 70.6%,and side-reactions were tolerable.Toxicity was tolerable.There was no treatment-related death.Conclusion:The chemotherapy has a high effective rate with acceptable toxicity in patient with metastatic breast cancer.更多还原