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绿原酸对小鼠免疫功能的影响

Effects of chlorogenic acid on immune function in mice

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【作者】 张建华姚素波刘洁张洁邱果包旭

【Author】 ZHANG Jian-hua1,YAO Su-bo2,LIU Jie3,ZHANG Jie4,Qiu Guo1,BAO Xu1* (1.West China School of Pharmacy,Sichuan University,Chengdu,Sichuan,610041 P.R.China;2.West China Hospital,Sichuan University,Chengdu,Sichuan,610031 P.R.China;3.Sichuan Institute of Chinese Material Medica,Chengdu,Sichuan,610031 P.R.China;4.Jiuzhang Biochemical Engineering Science and Technology Development CO.,LTD of Sichuan,Chengdu,Sichuan,610031 P.R.China)

【机构】 四川大学华西药学院四川大学华西医院四川省中药研究所四川成都四川九章生物化工科技发展有限公司

【摘要】 目的考察绿原酸对小鼠细胞免疫和体液免疫的影响。方法通过DNCB致小鼠耳肿胀的迟发超敏反应(DTH)、小鼠脏器巨噬细胞清除异物的功能、对5%鸡红细胞的吞噬功能的影响以及对环磷酰胺致小鼠溶血素低下的影响实验,研究绿原酸对机体细胞免疫和体液免疫的影响。结果绿原酸可明显增强DTH的耳肿胀度,增强巨噬细胞吞噬功能,提高机体血清溶血素的含量。结论绿原酸可明显增强机体细胞免疫和体液免疫的功能。

【Abstract】 OBJECTIVE To explore the effects of chlorogenic acid on immune function in mice.METHODS To study the effects of chlorogenic acid on the cell-mediated immunity and humoral-mediated immunity by experiments such as delayed-type hypersensitive response(DTH) induced by DNCB which resulted in ear swelling,the removing extraneous material function and the phagotrophy function to 5% CRBC of macrophage in organ and abdominal cavity,the effects on the low hemolysin in mice caused by cyclophosphamide.RESULTS Chlorogenic acid can enhance ear swelling of DTH,increase the macrophage phagocytosis function and the level of serum hemolysin.CONCLUSION Chlorogenic acid can obviously enhance the immune function on cell-mediated immunity and the humoral-mediated immunity.

  • 【文献出处】 华西药学杂志 ,West China Journal of Pharmaceutical Sciences , 编辑部邮箱 ,2009年04期
  • 【分类号】R285.5
  • 【被引频次】46
  • 【下载频次】497
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