【摘要】 目的研究4种不同配比的头孢噻肟钠/他唑巴坦钠(CTX/TAZ)(2:1、4:1、6:1、8:1)及头孢噻肟钠(CTX)单剂对四川地区临床分离致病菌的体外抗菌作用。方法采用平皿二倍稀释法测定465株临床分离致病菌的最低抑菌浓度(MIC)。结果联合配伍可以使金黄色葡萄球菌(MRSA)、表皮葡萄球菌(MSSE和MRSE)、粪肠球菌、大肠埃希菌(产ESBLs)、铜绿假单胞菌、阴沟肠杆菌、肺炎克雷伯菌(产ESBLs)和鲍曼不动杆菌等从CTX单用的MIC50值128～>256mg·mL-1降至2～64mg.L-1,下降幅度达4～128倍。结论不同配比的CTX/TAZ均有强大的杀菌作用,明显优于CTX单剂。6:1的CTX/TAZ复方制剂为较合理的配方组合,具有进一步的研究开发价值。更多还原

【Abstract】 OBJECTIVE To study the antibacterial activities of cefotaxime(CTX)and different ratios from matching cefotaxime/tazobactam(CTX/TAZ)(2:1,4:1,6:1,8:1)against clinically isolated pathogenic bacteria from Sichuan area in vitro.METHODS Minimal inhibitory concentrations(MIC)were determined by use of agar dilution method on 465 clinically isolated pathogenic bacteria.RESULTS MIC50 of CTX/TAZ with different ratios against Staphylococcus aureus(MRSA),Staphylococcus epidermidis(MSSE and MRSE),Enterococcus faecalis,Escherichia coli(ESBLs+),Pseudomonas aeruginosa,Aerobacter cloacae,Klebsiella pneumoniae(ESBLs+)and Baumanii were 2-64 mg L-1,which was 4-128 times lower than that of CTX alone.CONCLUSION Different formulas of CTX/TAZ(2:1,4:1,6:1,8:1)showed higher antibacterial activity against most clinical isolates than CTX alone in vitro.CTX/TAZ 6:1 is a better formulation and valuable to be investigated.更多还原