【摘要】 目的探讨抗心衰复方片(CTMC)对豚鼠慢性心力衰竭(CHF)心脏功能的影响。方法采用皮下反复注射异丙肾上腺素6周,制作豚鼠心肌缺血型CHF模型。观察CTMC对CHF豚鼠血流动力学、脏器/体质量比、病理改变和血清心肌肌钙蛋白-I(cTn-I)、肌酸激酶同工酶(CK-MB)含量的影响。结果CHF动物模型制作成功;CTMC可明显降低左室舒张压和左室舒张末压,中、大剂量组尤为显著;可显著提高左室收缩和舒张最大速率的绝对值,大剂量组更显著;明显减轻心肌细胞损伤和坏死;并可降低血清cTn-I、CK-MB含量,差异有统计学意义(P<0.01)。结论抗心衰复方片可改善CHF心脏的舒张功能和心肌细胞损伤,并呈现药物剂量依赖性。更多还原

【Abstract】 Objective To investigate the effect of a traditional Chinese medicine compound(CTMC)on chronic heart failure(CHF)in guinea-pigs.Methods The CHF of guinea-pigs were induced by repeated injection of hyodemic isoproterenol.The hemodynamics,organ(heart,lung,liver and kidney)/body weight ratio,pathological changes,and serum cTn-I and CK-MB were measured to determine the effectiveness of the traditional Chinese medicine treatement.Results The LVDP and LVEDP were decreased and the absolute value of +dp/dtmax and-dp/dtmax were increased by the administration of 10 mg/kg,20 mg/kg and 30 mg/kg of the compound tablets.The effect increased with doses.The traditional Chinese medicine also decreased the area of myocardial necrosis and the degree of injury to myocardiacyte.The intervention group had lower serum cTn-I and CK-MB levels than the controls.Conclusion The compound tablets can improve the left ventricular diastolic function of CHF and reduce the myocardial damage in a dose-dependent manner.更多还原