【摘要】 目的观察广东省潮汕地区汉族人群对氧磷脂酶1(PON1)L55M基因多态性与冠心病(CHD)合并空腹血糖升高(FHG)及2型糖尿病(T2DM)的相关关系,及与冠状动脉血管病变数和病变范围的相关关系。方法284例受检者据空腹血糖和冠状动脉造影结果分正常对照组(90例)、CHD组(86例)、CHD+FHG组(62例)、CHD+T2DM组(46例),进行SNPs序列测定入选人群PON1L55M基因并分析。结果广东地区汉族人群PON1L55M基因存在多态性,L等位基因频率为0.86。3种基因型(LL,LM,MM)在4组中无明显差异。L等位基因在冠心病病变血管数目和病变范围中无明显差异(χ2=0.56,P=0.758;χ2=0.11,P=0.743)。结论中国广东潮汕地区汉族人群中存在PON1L55M基因多态性,等位基因频率以L型为主。PON1L55M基因多态性与是否发生空腹血糖升高或糖尿病以及冠状动脉病变严重程度无明显相关性。更多还原

【Abstract】 Objective To investigate the relationships between Paraoxonase1(PON1)gene L55M polymorphism and coronary heart diseases(CHD)complicated with fasting hyperglycemia(FHG)or type 2 diabetes mellitus(T2DM).Methods Two hundreds and eighty four patients were recruited in this study,which comprised 86 patients with CHD,62 with CHD and FHG,46 with CHD and T2DM,and 90 patients without the above conditions.The sequences of the PON1 gene L55M polymorphism were analysed by the SNPs methods.Results The frequency of allele L was 0.86.No significant differences in the frequencies of the three genotypes(LL,LM,and MM)were found among the four groups of patients.The L allele of PON1 L55M was not associated with the number and range of coronary arterial lesions(χ2=0.56,P=0.76;χ2=0.11,P=0.74,respectively).Conclusion PON1 gene L55M polymorphism exists in Han populations in Guangdong,with LL as the main genotype.PON1 L55M gene polymorphism and allelic genes are not associated with the level of fasting blood glucose or diabetes mellitus.There is no evidence to support the relationship between PON1 L55M gene polymorphism and coronary artery lesions.更多还原