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南海红树林内生真菌ZSU-H26生物碱类代谢产物的研究

Alkaloid metabolites of mangrove endophytic fungus ZSU-H26 from the South China Sea

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【Author】 HUANG Zhong-jing1,2,YANG Rui-yun2,3,BAI Li-juan1,SHE Zhi-gang2,LIN Yong-cheng2(1.College of Chemistry and Ecology Engineering,Guangxi University for Nationalities,Nanning 530006,China;2.School of Chemistry and Chemical Engineering,Sun Yat-sen University,Guangzhou 510275,China;3.School of Chemistry and Chemical Engineering,Guangxi Normal University,Guilin 541004,China)

【机构】广西民族大学化学与生态工程学院；中山大学化学与化学工程学院；广西师范大学化学化工学院；

【Abstract】 Six alkaloids,2-(1H-indol-3-yl)-4H-benzo[d]oxazin-4-one(1),methyl o-(indole-3-carboxamido) benzoate(2),cyclo(Ile-Leu-Val-Va1)(3),cyclo(Phe-Gly)(4),cyclo(Leu-Leu)(5),and cyclo(Ala-Leu)(6),were isolated from the mangrove endophytic fungus ZSU-H26 from the South China Sea.Their structures were elucidated by spectral data.Indole alkaloids 1 and 2 were both isolated from microorganism for the first time.In the preliminary bioassay,1 and 2 show inhibitory activity on the hepG2 cell line with IC50 values of 20μg/mL and 35μg/mL,respectively.更多还原

【关键词】红树林内生真菌；代谢产物；生物碱；
【Key words】 mangrove endophytic fungus； metabolites； alkaloid；

【基金】国家863计划资助项目(2006AA09Z422);国家自然科学基金资助项目(20072058和20572136);广西自然科学基金资助项目(0832081);广西民族大学科学研究基金资助项目(200702YJ18)

【文献出处】化学研究与应用 ,Chemical Research and Application , 编辑部邮箱 ,2009年11期

【分类号】R284
【被引频次】9
【下载频次】304

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