节点文献
4-[(E)-2-(3,4,5-三甲氧基苯基)乙烯基]苯氧基羧酸酯的合成及抗肿瘤活性研究
Synthesis and anti-tumor activities of 4-[(E)-2-(3,4,5-trimethoxyphenyl) vinyl] phenoxy carboxylic ester
【Abstract】 Two new resveratrol analougues,t-butyl 4-[(E)-2-(3,4,5-trimethoxyphenyl)vinyl]phenoxy i-butyrate and ethyl 4-[(E)-2-(3,4,5-trimethoxyphenyl)vinyl]phenoxy n-butyrate,are synthesized from 3,4,5-trimethoxybenzaldehyde and p-nitrotoluene via mutil-steps including condensation,catalytic reduction,diazotization,hydrolyzation,nucleophilic substitution.The effect of the new compounds on HL-60 and A549 cell proliferation are tested by MTT.The results show that the two new compounds exhibite the activities of anti-tumor proliferation.
【关键词】 白藜芦醇类似物；
二苯乙烯衍生物；
抗肿瘤活性；
合成；
【Key words】 resveratrol analougues； stilbene derivatives； anti-tumor activities； synthesis；
【Key words】 resveratrol analougues； stilbene derivatives； anti-tumor activities； synthesis；
【基金】 教育部重点科学研究项目(105153)
- 【文献出处】 化学研究与应用 ,Chemical Research and Application , 编辑部邮箱 ,2009年01期
- 【分类号】TQ463.4
- 【被引频次】3
- 【下载频次】185