【摘要】 用三甘醇(TG)和柠檬酸(CA)通过熔融缩聚的方法得到了一种网络型阴离子聚醚酯—聚三甘醇柠檬酸酯(PTGC).用FT-IR对预聚物的结构进行了初步表征,用ATIR、DSC、XRD对材料的结构进行了表征.考察了PTGC在不同pH值缓冲溶液中的溶胀行为.实验结果表明,PTGC的溶胀度随着柠檬酸的比例的增加先减小后增大.在碱性介质中PTGC的溶胀度显著增大,而在酸性介质中溶胀度显著减小,在pH<3的缓冲液中的溶胀度达到最小值.在pH 7.4的人工肠液和pH 1.0的人工胃液中PTGC的溶胀-收缩具有可逆性,显示出良好的pH敏感性,有望作为pH敏感口服结肠定位给药系统药物载体.更多还原

【Abstract】 A novel anionic polyether-ester with pH-responsibility,poly(triethylene glycol citriate)(PTGC) was synthesized by using triethylene glycol(TG) and citric acid(CA).The chemical structure of the prepolymer was characterized by FTIR.The postpolymer was determined by ATIR,DSC and XRD.In the buffer solutions with different pH values,the swelling characteristics of PTGC were studied.The results shown that the swelling ratio of PTGC was decreased in the first and then increased with increasing the content of citric acid.PTGC swelled more significantly in alkaline solution than in acidic medium,the swelling ratio is the lowest at pH<3.0.PTGC showed swelling reversibility when soaked in pH 1.0 and pH 7.4 buffer solutions alternately.The results imply that PTGC could be potential pH sensitive carrier for colon-specific drug delivery system.更多还原