【摘要】 采用近红外漫反射光谱法对头孢氨苄粉末药品中主要成分头孢氨苄进行快速、无损定量分析。采用偏最小二乘法建立近红外光谱信息与待测组分含量间的最佳数学校正模型。对3种光谱(SNV光谱、一阶导数、二阶导光谱)的预测结果进行了比较,讨论了光谱的预处理方法和主成分数对偏最小二乘法定量预测能力的影响,并对预测集样品进行预测。更多还原

【Abstract】 A method for non-destructive quantitative analysis of cefalexin powder by near-infrared spectroscopy combined with partial least squares was investigated.The optimal calibration models for the determination of the concentrations of cefalexin were built simultaneously.Furthermore,three pretreated spectra(SNV spectra,first-derivative spectra and second-derivative spectra)were used and compared.The effects of pretreatment method and the number of principal components on the predicted ability of partial least squares models were discussed and the concentrations of cefalexin in the prediction samples were predicted.更多还原