【摘要】 目的:探讨周围型肺癌CT征象与血管内皮生长因子、E钙黏附蛋白表达间的关系。方法:本组58例周围型肺癌患者均采用螺旋CT扫描,采用免疫组织化学链菌素生物素蛋白-过氧化酶连接法检测肿瘤组织血管内皮生长因子、E钙黏附蛋白的表达。结果:E钙黏附蛋白异常表达32例,血管内皮生长因子异常表达35例,肺癌E钙黏附蛋白的异常表达与肿瘤的大小、棘突征、胸膜侵犯、淋巴转移明显相关(P<0.05)。肺癌血管内皮生长因子的异常表达与毛刺征、棘突征、血管集束征、空洞征胸膜侵犯、淋巴结转移明显相关(P<0.05)。结论:血管内皮生长因子和E钙黏附蛋白异常表达在肺癌的发生、发展及CT表现中可能起重要作用,检测该基因可作为临床诊断及预后评估的指标。更多还原

【Abstract】 Objective To investigate the correlation of spiral CT features with expression of E-cadherine and vascular endothelial cell growth factor in peripheral lung cancer.Methods Spiral CT scan were performed in 58 patients with peripheral lung cancer which confirmed by pathology.Expression of E-cadherine and vascular endothelial cell growth factor in 58 cases were examined with SP immunohistochemical techniques.Spiral CT findings were compared with expression of E-cadherine and vascular endothelial cell growth factor.Results The abnormal expression rate of vascular endothelial cell growth factor and E-cadherine was 63.34% and 55.17%.The abnormal expression of E-cadherine was associated with the CT features,such as lymph node metastasis,pleural invasion and the size of tumor(P<0.05),but the abnormal expression of vascular endothelial cell growth factor was associated with lymph node metastasis,pleural invasion and the size of tumor(P<0.05).Conclusion Vascular endothelial cell growth factor and E-cadherine gene over expression may play an important role in the pathogenesis and CT appearance of lung cancer and can be considered as a predicting marker of diagnosis and prognosis.更多还原