【摘要】 目的:了解本院临床分离细菌的分布特征及耐药谱,为合理使用抗生素提供依据。方法:大多数分离细菌的鉴定和药物敏感试验利用BD Phoenix仪,少数利用手工鉴定和Kirby-Bauer法。数据分析用WHONET5.4软件。结果:共分离出3 094株细菌,前3位为铜绿假单胞菌(11.2%)、大肠埃希菌(11.1%)和金黄色葡萄球菌(8.4%)。肠杆菌科耐药率<10%的为亚胺培南和头孢哌酮/舒巴坦,非发酵菌耐药率<10%的为头孢哌酮/舒巴坦。大肠埃希菌和肺炎克雷伯菌产超广谱β-内酰胺酶的检出率为47.5%和55.6%。革兰阳性球菌对万古霉素敏感率100%。金黄色葡萄球菌和凝固酶阴性葡萄球菌甲氧西林耐药率为52.1%和74.8%。结论:本院细菌耐药率居高不下,应加强抗生素的合理使用以降低耐药率。更多还原

【Abstract】 Objective To investigate the distribution and drug resistance spectrum of bacterial isolates in local region for using antibiotic reasonably.Methods Most bacteria isolates were identified by BD Phoenix,a few were identified by hand work and K-B method.WHONET5.4 was applied for analysis.Results The common isolates in 3 094 strains were P.aeruginosa(11.2%),E.coli(11.1%) and S.aureus(8.4%).In enterobactericaeae isolates,resistant rates of imipenem and cefoperazone/sulbactam were below 10%.In nonfermenters isolates,resistant rate of cefoperazone/sulbactam was below 10%.The incidences of E.coli and K.pneumoniae isolates producing extended spectrum beta-lactamase were 47.5% and 55.6%,respectively.In gram positive isolates,susceptible rate of vancomycin was 100%.The methecillin resistant rates of S.aureus and coagulase negative staphylococcus were 52.1% and 74.8%,respectively.Conclusion The resistant rates of bacteria in local region are high.It is important to promote the rational use of antimicrobial agents to reduce resistant rates of bacteria.更多还原