【摘要】 目的:对无症状性脑梗死患者的高敏C-反应蛋白、同型半胱氨酸、纤维蛋白原及血脂不同成分进行分析,探讨上述指标与无症状性脑梗死的关系。方法:高敏C-反应蛋白水平用免疫散射比浊法检测,同型半胱氨酸浓度用酶联免疫吸附法测定,纤维蛋白原用Thrombotimer4自动血凝仪测定,用Olimpus-AU5400全自动生化分析仪进行血脂相关成分的分析,共检测无症状性脑梗死患者216例,对照组210例。结果:无症状性脑梗死组高敏C-反应蛋白、同型半胱氨酸、纤维蛋白原和脂蛋白(α)的水平均较对照组明显升高(均P<0.01),而载脂蛋白A1水平则显著低于对照组(P<0.01);三酰甘油、总胆固醇、高密度脂蛋白、低密度脂蛋白和载脂蛋白B2组间比较差异无统计学意义(均P>0.05)。结论:高敏C-反应蛋白、同型半胱氨酸、纤维蛋白原和脂蛋白(α)升高及载脂蛋白A1降低均是无症状性脑梗死患者的高危危险因素。更多还原

【Abstract】 Objective To analyze high-sensitivity C-reactive protein,homocysteine,fibrinogen,and different components of serum lipid in patients with silent cerebral infarction and to explore the relationships between them and silent cerebral infarction.Methods The level of serum high-sensitivity C-reactive protein was measured with immunodiffusion turbidimetry.The serum homocysteine level was detected with ELISA.The plasma fibrinogen level was measured with thrombotimer 4 automatic blood coagulation instrument.The concentrations of serum lipid components were analyzed on the Olympus-AU5400 automatic biochemistry analyzer.A total of 216 silent cerebral infarction patients and 210 cases of control group were measured.Results The high-sensitivity C-reactive protein,homocysteine,fibrinogen and lipoprotein(α)levels in silent cerebral infarction group were significantly higher than those in control group,(18.72±5.20)mg/L vs(11.33±3.61)mg/L,(22.21±6.21)μmol/L vs(15.32±2.82)μmol/L,(5.23±2.31)g/L vs(2.84±1.46)g/L and(279.36±73.25)mg/L vs(214.24±47.68)mg/L,respectively(all P<0.01),but the concentration of ApoA1 in silent cerebral infarction group was markedly lower than that in control group,(1.33±0.28)g/L vs(1.43±0.32)g/L,(P<0.01).The concentrations of TG,TC,HDL,LDL and ApoB had no statistical significance between silent cerebral infarction group and control group(all P>0.05).Conclusion Increased high-sensitivity C-reactive protein,homocysteine,fibrinogen,lipoprotein(α)and decreased ApoB1 are all high-risk factors in patients with silent cerebral infarction.更多还原