【摘要】 目的:探讨抑阳酒连散对实验性急性葡萄膜炎模型大鼠房水及外周血TNF-α含量的影响。方法:采用内毒素诱导大鼠急性葡萄膜炎模型,随机分为抑阳酒连散组、雷公藤多甙组、模型组、空白组。连续灌胃7 d,灌胃第1天,3天,7天分别断尾取外周血和抽取房水测TNF-α;光镜下观察眼球病理形态学改变。结果:与模型组比较,抑阳酒连散组和雷公藤多甙组在造模后第1天、3天都能显著降低房水和外周血中的TNF-α(P<0.01);抑阳酒连散组与雷公藤多甙组比较,差异无统计学意义(P>0.05);造模后第7天,模型组、抑阳酒连散组、雷公藤多甙组之间比较,差异无统计学意义(P>0.05)。结论:抑阳酒连散能明显改善急性葡萄膜炎病理,有效抑制虹膜、脉络膜、视网膜的炎症反应,其作用可能与降低模型大鼠房水及外周血中的TNF-α有关。更多还原

【Abstract】 Objective:To investigate the influence of Yiyangjiuliansan on aqua oculi and TNF-αof peripheral blood in a-cute uveitis model rats.Methods:Acute uveitis model rats were established by endotoxin,they were randomly divided into Yiyangjiuliansan group(YG),Tripterygium wilfordii group(TWG),Model group(MG),Blank group(BG).intragastric administration for seven days continuously,on the 1st day,3rd day and 7th day,the model rats’ tail were cut off for taking peripheral blood and aqua oculi to test TNF-α,observing the change of pathomorphology under light microcope.Results:Compared with MG,YG and TWG could cut down TNF-αin peripheral blood and aqua oculi on 1st,3rd day(P<0.01),but YG contrasted to TWG,the difference had no statistical significance(P>0.05),on 7th day,Compared aomng YG,TWG,MG,the difference had no statistical significance(P>0.05).Conclusion:YG can improve the pathology of acute uveitis,inhibit inflammatory reaction on iris,choroid,retina effectively,its effects may be related with the loss of TNF-αin peripheral blood and aqua oculi.更多还原