【摘要】 目的:观察先天性心脏病介入封堵术前后血清心肌型脂肪酸结合蛋白(H-FABP)水平的动态变化并分析其影响因素。方法:选择室间隔缺损(VSD)患儿42例、动脉导管未闭(PDA)患儿36例、房间隔缺损(ASD)患儿30例,于介入治疗术前、术后15min、4h、24h测量血清H-FABP水平。采用多元线性回归分析影响血清H-FABP水平的相关因素。结果:各组术后15min、4hH-FABP水平较术前均升高(F时间=55.312,F组间=62.161,P均<0.01),高峰均出现在术后15min;多重线性回归分析显示病理类型、年龄、手术时间、封堵器释放次数是影响术后血清H-FABP水平的主要因素(β分别为0.666,-0.460,0.589,0.483,P均<0.05)。结论:先天性心脏病介入封堵术可引起可逆性的心肌微损伤,血清H-FABP水平升高程度与病理类型、年龄、手术时间、封堵器释放次数有关。更多还原

【Abstract】 Aim:To investigate the dynamics of serum heart-type fatty acid binding protein(H-FABP) level after interventional occlusion for congenital heart diseases(CHD) and to analyze its influence factors.Methods:A total of 108 patients,including 42 patients of ventricular septal defect(VSD),36 patients with patent ductus arteriosus(PDA),and 30 patients with atrial septal defect(ASD),were measured for the levels of H-FABP at baseline and 15 min,4 h,24 h after occlusion,respectively.And the influence factors of serum H-FABP level were analyzed by using multiple regression analysis.Results:The serum H-FABP level was significantly higher at 15 min,4 h after occulusion compared with those of pre-treatment respectively(Ftime=55.312,Fgroup=62.161,P<0.01),and the peak level of H-FABP occurred at 15 min.Multiple-linear regression model revealed the serum H-FABP peak level was correlated with pathological type,age,total time of intervention application,and times of occluders releasing,β was 0.666,-0.460,0.589,and 0.483 individually(P<0.05).Conclusion:Interventional occlusion in the patients with CHD might result in reversible,minor myocardial damage.Pathological types,age,total time of intervention application,and times of occluders releasing are influence factors for serum H-FABP peak level in patients with CHD.更多还原