【摘要】 目的:了解河南省艾滋病流行区艾滋病病毒(HIV)共感染乙型肝炎病毒(HBV)和丙型肝炎病毒(HCV)状况。方法:首先用Combas Amplicor HIV-1病毒载量检测法对从我省HIV某高发县采集的由输血感染HIV-1的130份血样进行定量测定。挑选出HIV-1病毒载量4.28×102拷贝/mL以上的血浆样本81份,同时收集30份HIV-1阴性健康体检者血浆作为对照,再用巢式PCR法对以上样本进行HBV和HCV测定。结果:81份HIV-1阳性样本中HBV阳性32份(39.5%),HCV阳性72份(88.9%);同时感染HBV和HCV的样本为7份(8.6%)。30份HIV-1阴性对照组中,HBV阳性7份(23.3%),与HIV-1阳性组间比较差异无统计学意义(χ2=2.51,P>0.05);HCV阳性4份(13.3%),与HIV-1阳性组间比较差异有统计学意义(χ2=57.88,P<0.05);HIV-1阴性对照组中未检测出HBV和HCV共感染样本,与HIV-1阳性组相比差异无统计学意义(χ2=2.77,P>0.05)。结论:经输血感染HIV的患者具有共感染HCV的倾向;对以上途径感染HIV的患者,在进行HIV治疗时应同时进行HBV和HCV检测,阳性者应在治疗HIV-1的同时给予抗HBV和HCV治疗。更多还原

【Abstract】 Aim:To investigate the relativity between HIV co-infected by HBV and HCV by blood transfusion.Methods:130 blood samples of HIV-1 infected by blood transfusion were collected by a high epidemic county, Henan. 81 samples which HIV-1 virus numbers over 4.28×102 copies/mL were selected and 30 blood samples of health human were collected. HBV and HCV were determined by the above samples and by nested PCR.Results: In 81 HIV-1 positive samples, 32 were HBV positive (39.5%); 72 were HCV positive (88.9%); 7 were HBV+HCV positive (8.6%). In 30 HIV-1 negative samples, 7 were HBV positive (23.3%) (P>0.05); 4 were HCV positive (13.3%) (P<0.05); no samples was HBV+HCV co-infected positive (P>0.05).Conclusions: Patients who were infected HIV by blood transfusion could be infected HCV at the same time. When the persons were treated for anti-HIV medicine, they would be checked up HBV and HCV. If the HIV patients are HBV and/or HCV positive, they would be treated by anti HBV and/or HCV medicine, too.更多还原