【摘要】 目的探讨白介素-6水平与脑梗死早期神经症状恶化的关系。方法206位首发脑梗死发病24h内入院病人为研究对象。脑卒中患者临床神经功能缺损程度评分在入院后48h内上升至少1分定义为神经症状恶化。入院后检测206例病人血浆白介素-6水平,其中98例病人同时取样检测脑脊液白介素-6水平。结果66例(32%)病人在48h内恶化。血浆白细胞介素或脑脊液白细胞介素是早期临床恶化独立因素。血浆白细胞介素-6水平与病人体温、血糖、纤维蛋白原和脑梗死体积高度相关。结论白细胞介素-6除了参与局部脑缺血后急性期反应外,其水平还与早期临床恶化相关。白细胞介素-6水平检测可作为急性脑缺血预后指标。更多还原

【Abstract】 Objective To assess the implication of interleukin-6(IL-6) in early neurological worsening in cerebral infarction.Methods Two hundred and six patients consecutively admitted with first-ever ischemic cerebral infarction within the first 24 hours from onset were selected.Neurological worsening was defined when the Chinese Stroke Scale(CSS) score added at least 1 point during the first 48 hours after admission.IL-6 was determined in plasma and cerebrospinal fluid(n=98) obtained on admission.Results Sixty-six patients(32%) deteriorated within the first 48 hours.IL-6 in plasma or CSF were independent factors of early clinical worsening.IL-6 in plasma was highly correlated with body temperature,glucose,fibrinogen,and infarct volume.Conclusion In addition to participating in the acute-phase response that follows focal cerebral ischemia,IL-6 levels on admission are associated with early clinical deterioration.The measure of level of IL-6 can be taken as index of prognosis of acute cerebral infarction.更多还原