节点文献
1-[苯基(4-甲氧苯基亚胺基)甲基]-3-(1-萘基)硫脲的合成
Synthesis of 1-[(4-Methoxyphenylimino)phenylmethyl]-3-(naphth- alen-1-yl) thiourea
【摘要】 以N-(4-甲氧基)苯基苯甲酰胺和二氯亚砜为原料,经氯代反应制得氯代4-甲氧基苯基苯甲酰亚胺(2),2与硫氰酸钠加成得中间体N-(异硫氰酸基(苯基)亚甲基)-4-甲氧基苯胺(3)后,与1-萘胺经加成反应合成得到最终产物1-(苯基(4-甲氧苯基亚胺基)甲基)-3-(1-萘基)硫脲(4),总收率为72.6%。合成化合物3的适宜工艺条件为:n(2)∶n(硫氰酸钠)=1∶1.2,丙酮为溶剂,反应温度为-15℃,反应时间3h。
【Abstract】 The title compound 4 was prepared in several steps. Chlorinated compound, N-(4-methoxyphenyl) benzimidoyl chloride (2) was synthesized from N-(4-methoxyphenyl) benzamide and thionyl chloride. Addition of sodium thiocyanate to 2 followed by reaction with naphthylamine afforded the title compound in an overall yield of 72.6%.
【基金】 黑龙江省教育厅科学技术研究项目资助(1153G043)
- 【文献出处】 精细化工中间体 ,Fine Chemical Intermediates , 编辑部邮箱 ,2009年06期
- 【分类号】TQ246.3
- 【被引频次】1
- 【下载频次】101