【摘要】 目的探讨钙通道阻滞剂维拉帕米对重症急性胰腺炎(sever acute pancreatitis,SAP)大鼠肺损伤的影响。方法Wistar大鼠45只,随机分为假手术组、SAP组和维拉帕米治疗组。观察动物血清中白细胞介素1(interleukin-1,IL-1)、白细胞介素6(interleukin-6,IL-6)和肿瘤坏死因子-α(tumer necrosis factor-α,TNF-α)的含量,肺组织病理学变化。结果SAP大鼠血清中IL-1、IL-6和TNF-α的含量均显著升高(P<0.01),肺损伤严重。维拉帕米治疗组炎性细胞因子水平显著下降(P<0.05),肺病理损害程度显著减轻(P<0.05)。结论维拉帕米可抑制SAP大鼠炎性细胞因子IL-1、IL-6、TNF-α的产生和释放,减轻肺损伤的程度。更多还原

【Abstract】 Objective To explore the effect of calcium channel blockers(CCB)verapamil on lung injury of rats with sever acute pancreatitis(SAP).Methods 45 Wistar rats were randomly divided into group A(sham-operative group),group B(SAP group)and group C(SAP treated with verapamil).The contents of interleukin-1(IL-1),interleukin-6(IL-6)and tumer necrosis factor-α(TNF-α)in serum were measured and the pathology alteration of lung were observed.Results In group B the levels of serum IL-1,IL-6 and TNF-α increased significantly as compared to those in group A(P<0.01)and the pathologic damage of lung was severe.In group C,the levels of serum IL-1,IL-6,TNF-α were remarkably lower than those in group B(P<0.05),and the severity of lung injury was dramatically reduced(P<0.05).Conclusion During the course of SAP,verapamil could reduce the contents of IL-1,IL-6,TNF-α and has beneficial effect on lung injury.更多还原