【摘要】 5-苄基-4-叔丁基-2-氨基噻唑与芳香醛缩合制备了1 1种5-苄基-4-叔丁基-2-苄亚氨基噻唑.结构经1H NMR和元素分析确证,并用单晶X-射线衍射测定了化合物Ⅰc的晶体结构.化合物Ⅰc晶体属单斜晶系,空间群为P21/n,晶胞参数为:a=1.43753(11)nm,b=0.98665(8)nm,c=1.46565(12)nm,β=114.2560(10)°;Z=4,V=1.8953(3)nm3,Dc=1.349 g/cm3,F(000)=808,R1=0.0507,wR2=0.1163,S=1.03.体外筛选结果表明,化合物Ⅰb,Ⅰk在10μmol/L浓度下对COX-2的抑制率超过50%.更多还原

【Abstract】 Eleven new 5-benzyl4-tertbutyl-2benzyliminothiazoles were synthesized through the reaction of 5-arylmethyl-4-tert-butylthiazol2-amine and aromatic aldehyde.Their structures were established with 1 H NMR spectra and elemental analysis.The crystal structure of compound Ⅰc has been determined by X-ray diffraction analysis.The compound Ⅰc crystal belonges to monoclinic system with space group P21/n and cell parameters:a=1.437 53(11) nm,b= 0.986 65(8)nm,c=1.465 65(12) nm,β=114.256 0(10)°;Z=4,V=1.895 3(3) nm3,Dc=1.349 g/cm3,F(000)=808,R1=0.050 7,wR2=0.116 3,S=1.03.Biological tests showed that compound Ⅰb,Ⅰk exhibited ≥50% inhibition rate against COX2 in vitro.更多还原