【摘要】 目的探讨雌、孕激素受体表达在不同病理类型脑膜瘤中的意义。方法采用S-P免疫组化法检测38例脑膜瘤组织中雌、孕激素受体的表达,分析其与病理类型的关系。结果雌激素受体在脑膜瘤组织中表达率7.89%(3/38),孕激素受体表达率63.15%(24/38)。孕激素受体在良性患者表达率71.87%(23/32),非良性患者表达率16.67%(1/6),比较差异有统计学意义(P<0.05),孕激素表达与患者年龄、性别无关。结论孕激素受体表达与脑膜瘤的发生、发展和肿瘤良、恶性有关,其表达率可作为临床诊断治疗的参考。更多还原

【Abstract】 ObjectiveTo investigate the clinical significance and the expressions of ER and PR in meningiomas.MethodsImmunohistochemical method was used to examine ER and PR of the sections from 38 cases with meningiomas.ResultsThe positive rate of ER and PR expressions in meningiomas were 7.89%(3/38),63.15%(24/38) respectively. The positive rate of PR expressions was 71.87%(23/32),16.67%(1/6) in benign and malignant meningiomas respectively. The positive rate of PR expressions in benign meningiomas was significantly higher than that in malignant meningiomas (P<0.05) and was not related to age,differentiation or pathological type.ConclusionThe results suggest that the expressions of PR involve in genesis and development of meningioma and may be related to benign and malignant meningioma. Detection of PR could be used as a factor in diagnosis and therapy for the patients.更多还原