【摘要】 目的比较放化疗同步和序贯治疗中晚期非小细胞肺癌的临床疗效。方法选择不能手术的中晚期非小细胞肺癌69例,随机分成两组,同步治疗组:放疗、化疗同时进行;序贯组:化疗2周期后再行放疗。化疗方案为NP,放疗剂量68.0~72.0 Gy。结果治疗总有效率:同步组74.2%,序贯组50.0%,两组比较差异有统计学意义(P<0.05);达到上述有效率所用的时间,同步组72 d,序贯组150 d,两组比较差异有统计学意义(P<0.01);两组生存率比较差异无统计学意义(P>0.05);两组患者均能耐受治疗中的毒副反应。结论同步组的近期疗效优于序贯组,且治疗毒副反应未见明显增加。更多还原

【Abstract】 ObjectiveTo evaluate the clinical effects of sequential therapy and concurrent therapy on middle and advanced stage non-small cell lung cancer(NSCLC).Methods69 patients with middle and advanced stage NSCLC were randomized into two groups.38 patients of the sequential group received two cycles chemotherapy and then underwent radiotherapy.31 patients of the concurrent group were performed radiotherapy on the first day in the first circle chemotherapy.The regimen of chemotherapy: NVB and DDP.The regimen of radiotherapy patients were received a dose of 68.0~72.0 Gy.ResultsThe overall response(CR+PR) was 74.2% in the sequential group and was 50.0% in the concurrent group(P<0.05).The treatment course was 72 days and 150 days for the sequential group and concurrent group respectively(P<0.01).There was no significant difference between survival rates of the two groups.The toxic effects could be tolerable by all the patients.ConclusionThe concurrent chemo-radiotherapy has better overall response than the sequential chemo-radiotherapy.更多还原