【摘要】 目的了解隐匿性乙型肝炎病毒(HBV)感染在孕妇人群中的发生率及母婴传播状况,为制订干预措施提供依据。方法对1 000例血清学检测HBsAg阴性的孕妇进行HBV-DNA检测,阳性者为隐匿性HBV感染,对隐匿性HBV感染孕妇分娩的新生儿进行HBV血清学检测及HBV-DNA检测。统计孕妇人群隐匿性HBV感染的发生率,以及通过母婴传播引起新生儿隐匿性HBV感染的发生率。结果1 000例HBsAg阴性孕妇中,检测出隐匿性HBV感染病例57例(5.7%),其分娩的新生儿检测出隐匿性HBV感染8例(14.0%)。阳性组新生儿母亲HBV-DNA含量显著高于阴性组(P<0.01)。结论孕妇人群中存在一定数量的隐匿性HBV感染,并能通过母婴垂直传播引起胎儿宫内感染;新生儿隐匿性HBV感染的发生率与母亲血清中HBV-DNA含量密切相关。更多还原

【Abstract】 Objective To explore the rate of occult hepatitis B virus(HBV) infection in pregnant women and the status quo of maternal-neonatal transmission and to provide information for interventional measures.Methods Totally,1 000 HBsAg negative pregnant women were given HBV-DNA detection,and those with positive results were diagnosed as occult HBV infection and their babies received serous HBV and HBV-DNA detection.The incidence rates of occult HBV infection in pregnant women and their newborns were calculated.Results Fifty seven HBsAg negative women were diagnosed as occult HBV infection,among whose babies,8 were infected,with the incidence rate being 14.0%.The quantity of HBV-DNA was significantly higher in HBsAg positive women than that in HBsAg negative ones(P<0.01).Conclusion Occult HBV infection can be found in some pregnant women,and it can be transmitted by maternal-neonatal transmission.The incidence rate of occult HBV infection in newborns is correlated with HBV-DNA quantity of its mother.更多还原