【摘要】 目的:比较甲苯胺红不加热血清试验(TRUST)、螺旋体明胶颗粒凝集试验(TPPA)两种梅毒血清学试验的检测结果。方法:将2008~2009年性病门诊138例确诊梅毒患者血清同时用甲苯胺红不加热血清试验TRUST试验、螺旋体明胶颗粒凝集试验TPPA试验检测,比较两种梅毒检测实验方法的灵敏度和特异性。结果:138份血清中,98份血清TRUST阳性,17份经抗梅毒治疗血清TRUST阴性,TPPA试验132份血清为阳性。结论:TRUST试验可作为梅毒的人群筛查、疗效、复发或再感染的检测指标,TPPA试验是检测梅毒螺旋体抗体的特异性方法,主要作为梅毒的确证试验。两种不同方法同时进行梅毒检测,将减少漏诊、误诊率,为梅毒的确诊提供参考依据,并且在判定梅毒的发展、痊愈及药物疗效方面都具有十分重要的意义。更多还原

【Abstract】 Objective:to select the best screening method suiting for blood donors by assessing the validity of TRUST and TPPA.Methods:TRUST was used to screen patients with syphilis from blood donors,and TPPA was used to confirmed positive results detected by TRUST.Results:the sensitivity,false positive rate and false negative rate of TRUST were 39.02%,3.03%,and 60.98% respectively.The sensitivity,false positive rate and false negative rate of ELISA were 98.73%,20.59% and 1.22%.Conclusions:The combination of TRUST and ELISA is the first choice to screen patients with syphilis from blood donors.Moreover this screening contributes to blood safety.更多还原