【摘要】 目的观察奥施康定(盐酸羟考酮控释片)治疗原发性肝癌肝动脉化疗栓塞术后引起中重度肝区疼痛的近期疗效和不良反应。方法初始剂量10 mg/12 h,服用24 h如疼痛分级下降不到1级,则第2天加量至20 mg/12h。服用24 h如疼痛分级仍下降不到1级,第3天加量至30 mg/12 h,以此类推,最多至40 mg/12 h。结果总有效率(CR+PR)为95.4%,中度疼痛组有效率为95.2%,重度疼痛组有效率为95.8%。不良反应:便秘者19例(28.8%),恶心、呕吐者8例(12.1%)。结论服用盐酸羟考酮控释片治疗肝动脉化疗栓塞术后出现中重度肝区疼痛安全有效。更多还原

【Abstract】 Objective To evaluate the efficacy and side effects of oxycontin(oxycodone hydrochloride controlled-release tablets)in the treatment of moderate to severe hepatalgia of primary liver cancer post-transcatheter arterial chemoembolization.Methods Oxycontin was administered at an initial dose of 10mg every 12 hours and the dose was increased to achieve pain relief.If the pain was decreased less than one grade after 24 hours,the dosage was increased to 20mg/12h the next day.If the pain was still decreased less than one grade,the dosage on the third day was increased to 30mg/12h.The maximum dosage was 40mg/12h.Results The overall relief rate from pain was 95.4%.95.2% in patients with moderate hepatalgia and 95.8% in patients with severe hepatalgia.Conclusion Oxycontin is safe and effective for moderate and severe hepatalgia of primary liver cancer post-transcatheter arterial chemoembolization.更多还原