【摘要】 介绍了合成喹诺酮药物一些重要中间体所取得的新进展,这些中间体包括:2,3,4-三氟-4-硝基苯、2,4-二氯-5-氟苯甲酸、4-丁酰氯、2,6-二氯-5-氟烟酰乙酸乙酯、2,4-二氯-5-氟苯乙酮、2,4-二氯氟苯等。另外,对某些合成方法的改进作了较详细叙述,如:2,4-二氯氟苯、2,4-二氯-5-氟苯甲酸等。如其中以1,2,3-三氯苯为起始原料,经硝化、氟化两步反应制得的1,2,3-三氟-硝基苯产品质量分数大于99%,收率达60%。更多还原

【Abstract】 New advance of some important intermediates for synthsizing quinolone antibacterial was introduced. These intermediates include 2, 3, 4- trifluoronitrobenzene - 4 - nitrobenzene, 2, 4 - dichlor - 5 - fluorobenzoic acid, 4 - nbutyryl chloride ,2,4 - dichlor - 5 - fluorobenzonic acid and ethyl - 2,6 - dichlor - 5 - fluoro nicotinoy acetate, and 2,4dichlor fluorbenzene etc.. In addition, expounded improvement of some synthetic methods, such as 2,4 - dichlor fluorbenzene,2,4 - dichlor - 5 - fluorobenzoic acid, etc. , if taking 1,2,3 - trifluoro - 4 - nitrobenzene sythesized by two processes of nitration and fluorinatin with 1,2,3 -trichlorobenzene as raw material. Content and of product was over 99%, and yield was 60%.更多还原