【摘要】 以4-反式-正丙基环己基甲酸(Ⅰ)为原料,经过LiAlH4的还原,得到4-反式-正丙基环己基甲醇(Ⅱ),再经过溴代反应,合成了4-反式-正丙基环己基溴代甲烷(Ⅲ),此溴代物制备成格氏试剂与CO2气体反应得到目标化合物4-反式-正丙基环己基乙酸(Ⅳ),总产率47.9%。并对产物用GC-MS,1HNMR进行了表征。此种方法较文献上普遍采用的合成方法有了较大的改进,提高收率、降低成本,并且避免了KCN、NaCN这样的剧毒物的使用。更多还原

【Abstract】 4-Trans-(n-propyl)cyclohexyl acid(Ⅰ)was reducted with LiAlH4 to pruduce the 4-trans-(n-propyl)cyclohexyl methanol(Ⅱ).The compound Ⅱ was bromized to produce the 4-trans-(n-propyl)cyclohexyl bromic methane(Ⅲ).And then the goal product 4-trans-(n-propyl)cyclohexyl acetic acid(Ⅳ) was abtained from treatment of Grignard rengent from compound Ⅲ with carbon dioxidein overall yield of 47.9%.And the structure of the goal compound are characterized by means of GC-MS,1HNMR.This method has more advantageous than synthesis method by mentioned in the past literature such as increasing yield,decreasing cost,nontoxicity.更多还原