【摘要】 目的:观察短期甘精胰岛素用于初发2型糖尿病(T2DM)患者的疗效及胰岛β细胞功能和胰岛素敏感性的改变。方法:36例初发T2DM并空腹血糖(FPG)≥11.1 mmol/L的患者,给予甘精胰岛素每晚22:00左右皮下注射,配合午餐及晚餐前使用短效人胰岛素,治疗2周后停药随诊观察。结果:甘精胰岛素治疗2周显示稳定、快速降糖效果,治疗后口服糖耐量试验出现明显增加的C肽曲线下面积;胰岛素分泌指数明显增加;胰岛素抵抗指数显著改善。随访患者中最长的已有4个月不用药物,仅靠饮食控制和运动血糖就能很好地控制。结论:对伴明显高血糖的初次诊断T2DM患者,短期甘精胰岛素强化治疗可以快速、稳定控制血糖,显著改善胰岛β细胞功能和胰岛素敏感性。更多还原

【Abstract】 Objective:To investigate the effects of short-term insulin glargine on plasma glucose,and the change of beta-cell function and insulin resistance in Primary type 2 diabetes mellitus(T2DM) patients.Method :36 newly diagnosed T2DM cases complicated with fasting plasma glucose(FPG)≥11.1 mmol/L,were treated with glargine insulin around 22:00 each day and regular human insulin before lunch and dinner each day.After two weeks the patients were followed by the withdrawal of medicine.Result:The excellent control of plasma glucose was achieved after 2 weeks treatment with glargine insulin.Beta-cell function was dramatically improved.The secretion index of insulin and C-peptide curve area as well as Homa-β were sign were obviously increased during OGTT.Re-examined patients stopped using of medicine for at most four months,whose plasma glucose could be controlled only by controlling of diet and exercise.Conclusion:The excellent glucose control,improvement of beta-cell function,and amelioration of insulin resistance can be induced by short-term glargine treatment in Primary type 2 diabetic patients.更多还原