【摘要】 以2(或4)-氯间苯二酚和乙酰乙酸乙酯为原料,通过Pechmann缩合反应,合成了新的8(或6)-氯-7-羟基-4-甲基香豆素(1a或1b);1经硫酸二甲酯甲基化得2a或2b;以四正丁基溴化铵作相转移催化剂,1经Wil-liamson反应合成了6个新的氯代香豆素衍生物(3a～6a,3b,4b),产率66%～92%。1～6的结构经1H NMR,IR和GC-MS表征。更多还原

【Abstract】 8(or 6)-Chloro-7-hydroxy-4-methylcoumarin(1a or 1b) was prepared by Pechmann condensation between resorcinol chloride and ethyl acetoacetate. 1 reacted with dimethyl fulfate and produced 2a or 2b. Six new 7-alkylox-8(or 6)-chloro-4-methyl coumarins(3a~6a,3b and 4b) in yields of 66%~92% were synthesized via Williamson reaction of 1 and alkyl halides using tetrabutylammonium bromide as a phase transfer catalyst. The structures of 1～6 were characterized by 1H NMR,IR and GC-MS.更多还原