【摘要】 目的研究Caveolin-1、增殖细胞核抗原(PCNA)在胶质瘤的表达,探讨其与肿瘤恶性程度及预后的关系。方法用SP免疫组化技术检测60例胶质瘤标本及8例正常脑组织中Caveolin-1、PCNA的表达,分析其在胶质瘤中表达的关系及与肿瘤病理级别之间的关系。结果Caveolin-1随胶质瘤病理级别的增高阳性表达率下降,在正常脑组织、低级别和高级别胶质瘤各组间比较差异有统计学意义(P<0.05)。PCNA随着病理级别的增高阳性表达率升高,在正常脑组织、低级别和高级别胶质瘤各组间比较差异亦有统计学意义(P<0.05),PCNA与Caveolin-1在胶质细胞瘤中的表达呈负相关性(r=-0.604,P<0.05)。结论Caveolin-1的表达对胶质瘤细胞增殖起抑制作用,而PCNA的表达与肿瘤组织分化、恶性程度及预后相关。Caveolin-1与PCNA的表达存在负相关性,Caveolin-1是影响胶质瘤发生发展的重要因素。更多还原

【Abstract】 Objective To investigate the expression and significance of caveolin-1 and PCNA in gliomas and to explore the correlation between the two factors and the malignant degree of tumor as well as patients’prognosis.Methods The SP immunohistochemistry technique was used to detect the expression of caveolin-1 and PCNA in 60 cases of gliomas tissues and 8 cases of normal brain tissues(control group).Results The expression of caveolin-1 was decreased with the increase of pathological grade of gliomas.There were significant differences in the expression of caveolin-1among normal brain tissue,low-grade gliomas and high-grade gliomas(P<0.05).The expression of PCNA was increased with the increase of pathological grade of gliomas.There were significant differences in the expression of PCNA among normal brain tissue,low-grade gliomas and high-grade gliomas(P<0.05).The expression of PCNA was negatively related with the expression of caveolin-1.Conclusion The expression of caveolin-1 has inhibition effect on the cell proliferation of gliomas,while the expression of PCNA is related with tumor histodifferentiation,malignant grade and patients’ prognosis,and Caveolin-1 is an important factor to affect the pathogenesis and development of gliomas.更多还原