【摘要】 目的检测未足月胎膜早破(PPROM)与足月胎膜早破(足月PROM)孕妇血清降钙素原(PCT)的浓度,探讨其与胎膜早破的关系及对PPROM患者绒毛膜羊膜炎的预测价值。方法选取PPROM患者55例,相同孕周健康孕妇40例;足月PROM患者40例,相同孕周健康孕妇40例,进行血清PCT检测,孕足月PROM及PPROM患者分娩后胎盘胎膜病理检查。结果孕足月PROM及PPROM组孕妇血清中PCT阳性率均高于相应对照组(P<0.05);但足月PROM及PPROM组孕妇血清中PCT比较,差异无统计学意义(P>0.05)。且PPROM组中存在组织学绒毛膜羊膜炎者与无绒毛膜羊膜炎者血清PCT差异无统计学意义(P>0.05);PCT诊断PPROM患者组织学绒毛膜羊膜炎的敏感性、特异性分别为60.00%、35.00%(PCT>0.5μg/L);37.00%、60.00%(PCT>2μg/L)。结论PCT在PPROM及孕足月PROM孕妇血清中浓度升高,但其对PPROM患者绒毛膜羊膜炎的预测价值尚待进一步研究。更多还原

【Abstract】 Objective To investigate the relationship between maternal plasma procalcitonin(PCT)and premature rupture of membranes(PROM)by detecting the concentration of PCT in pregnant women,and to explore the significance of PCT in the diagnosis of chorioamnionitis in pregnant wome with PPROM.Methods The serum PCT concentrations were measured in 55 pregnant women with PPROM and 40 healthy pregnant women at same pregnant term.40 pregnant women with PROM at term and 40 healthy pregnant women at same pregnant term,and Hematoxylin Eosin(HE)staining of placenta were performed after delivery of PPROM and PROM at term cases to observe the pathological changes of membranes of placenta.Results The positive rates of PCT in pregnant women with PPROM and PROM at term were significantly higher than those in control group(P<0.05),however,there was no significant difference in the positive rates of PCT between pregnant women with PPROM and pregnant women with PROM(P>0.05).Furthermore there was no significant difference in the positive rates of PCT between PPROM group with chorioamnionitis and PROM group without chorioamnionitis(P>0.05).The sensitivity and specificity in pregnant women with PPROM identified according to PCT concentration were 60.00%,35.00%(PCT>0.5μg/L);37.00%,60.00%(PCT>2μg/L).Conclusion The PCT concentration in pregnant women with PPROM or PROM at term is increased,but its diagnostic value for chorioamnionitis in patients with PPROM needs to be researched further.更多还原