【摘要】 目的探讨小剂量阿米替林对腹泻型肠易激综合征的疗效和耐受性。方法入选64例患者随机分为治疗组和对照组,治疗组每晚给予阿米替林12.5mg,安慰剂组每晚给予维生素C50mg,治疗6周后评价疗效及药物不良反应。结果64例患者全部完成治疗。治疗组症状全部都有改善,症状平均分从2.9分降为0.8分,与治疗前比较差异有统计学意义(P<0.05),总有效率为71.9%,与对照组比较差异有统计学意义(P<0.05),2组不良反应发生率差异无统计学意义(P>0.05)。结论小剂量阿米替林治疗腹泻型肠易激综合征有效,患者耐受性好。更多还原

【Abstract】 Objective To investigate the clinical effects and tolerance of low-dose amitriptyline in the treatment of diarrhoea-predominant irritable bowel syndrome. Methods 64 patients were randomly divided into two groups,the amitriptyline group(taking amitriptyline 12.5mg/d) and the placebo group(taking vitamin C 50ng/d). The patients’ symptoms and adverse effects were evaluated after 6-week treatment.Results All the patients completed the therapeutic course. The patients’symptoms were improved significantly,and the mean number of symptoms decreased significantly from 2.9 to 0.8 in amitriptyline group(P<0.05). The total effective rate was 71.9%,and there was a significant difference between amitriptyline group and placebo group(P<0.05). But the adverse effects were similar between two groups(P>0.05).Conclusion Low-dose amitriptyline may be effective in treating diarrhoea predominant irritable bowel syndrome,with well tolerance.更多还原