【摘要】 目的观察大黄所致慢传输型便秘大鼠结肠肌间神经丛的变化,揭示大黄与该病发展的相关性。方法利用中药大黄制作大鼠慢传输型便秘动物模型,观察结肠传输功能及生长抑素(SOM)、P物质(SP)的表达,结肠肌间神经丛病理及超微结构变化。结果大黄模型组结肠传输功能缓慢;黏膜慢性炎症,全层大量嗜酸性粒细胞浸润;肌间神经丛神经细胞空泡变性、减少;结肠肌间神经丛内未找到Cajal间质细胞,大鼠结肠肌间神经丛SOM、SP含量较对照组明显下降(P<0.01)。结论大黄等蒽醌类泻剂损伤结肠壁神经丛,使结肠传输功能下降。因此,对慢传输型便秘患者治疗时,应避免长期应用此类药物。更多还原

【Abstract】 Objective To observe the changes in colon myenteric plexus of rhubarb-induced slow-transit constipation in rats,to investigate the correlation between rhubarb and the development of the disease.Methods The rats were fed with rhubarb to make the animal models of slow transit constipation.The transfer function of the colon and somatostatin(som),P material(sp)expression,colon myenteric plexus pathological and ultrastructural changes were detected.Results The rhubarb model group slowed colonic transit function;mucosal chronic inflammation,a large number of full-thickness eosinophil infiltration;myenteric plexus nerve cell degeneration and increase,and colon myenteric plexus was not found in the interstitial Cajal cells and rat colon myenteric plexus SOM,and the content of SP was significantly decreased,as compared with that of control group(P<0.01).Conclusion The rhubarb anthraquinones can damage cathartic colon wall plexus,reduce the function of colonic transit.Therefore,for the patients with slow transit constipation,the long-term application of such substances should be avoided.更多还原