【摘要】 目的通过对实施体外受精-胚胎移植（in vitro fertilization-embryo transfer,IVF-ET）患者基础血清中促卵泡素（follicle stimulating homore,FSH）、黄体生成素（luteinizing hormone,LH）、雌二醇（estuarial,E₂）水平、FSH/LH及基础血清、卵泡液中抑制素B（inhibin-B,INH-B）水平的测定;B型超声监测卵巢体积及窦卵泡数量,探讨在控制下卵巢刺激时卵巢对促排卵药的反应能力。方法选取在河北医科大学第二医院生殖中心接受IVF-ET42例患者进行回顾性分析。结果卵巢反应正常组与卵巢反应不正常组比较年龄及基础血清FSH、INH-B,卵泡液INH-B、平均卵巢体积、窦卵泡数量水平差异有统计学意义（P<0.05或P<0.01）。结论基础血清FSH水平是预测卵巢反应最好的独立指标。多因素综合考虑时,年龄、卵泡液中INH-B水平对预测卵巢反应有统计学意义。年龄与基础血清FSH、INH-B及卵泡液中INH-B水平结合可更好的预测卵巢反应。更多还原

【Abstract】 Objective To identify and quantify several predictors of ovarian response[age, basal levels of serum follicle stimulating homore（FSH）,luteinizing hormone（LH）,FSH/LH, estradiol（E₂）and inhibin-B（INH-B）in serum,and INH-B in follicular fluid,mean ovarian volume and total number of antral follicles] in controlled ovarian stimulation（COS）.Methods Forty-two females who had undergone IVF-ET in the Second Hospital of Hebei Medical University from Mar 2004 to Oct 2006 were retrospectively analyzed.Results There were statistical significance between the normal response group and the low response group,in these predictors（age,basal levels of serum FSH and INH-B and INH-B in follicular fluid.Mean ovarian volume and total number of antral follicles）.Conclusion The basal level of serum FSH was the best independent predictor.When all factors were considered,the female age and the level of INH-B in follicular fluid have statistical significance as the predictors of ovarian response.Age is a better predictor than the level of INH-B in follicular fluid.Age,combined with levels of serum FSH and INH-B in serum and in follicular fluid could well predict the ovarian response.更多还原