【摘要】 目的探讨阿仑膦酸钠（alendronate,ALN）对绝经后女性骨质疏松症的疗效以及对骨代谢的作用。方法选取用双能X线骨密度仪测定的绝经后女性骨质疏松症患者30例,以ALN联合钙剂治疗6个月,检测骨密度（bone mineral density,BMD）变化,并测定治疗前后血清骨钙素（bone gla protein,BGP）、碱性磷酸酶（alkalinephosphatase,ALP）、钙（calcium,Ca）、磷（phosphorus,P）等水平的变化。结果绝经后女性骨质疏松症患者服用ALN 6个月后腰椎（L₂～L₄）BMD显著增高（P<0.01）,血清BGP、ALP、P水平显著降低（P<0.01）。结论服用ALN 6个月可提高绝经后女性骨质疏松症患者腰椎BMD,降低骨代谢指标BGP水平。更多还原

【Abstract】 Objective To observe the effect of alendronate on bone metabolism and bone mineral density（BMD）in Chinese postmenopausal osteoporotic women.Methods BMD of 30 Chinese postmenopausal osteoporotic women were measured by double-x ray bone mineral density meter.The changes in BMD and the level of serum osteocalcin（bone gla protein,BGP）,alkaline phosphatase（ALP）,calcium（Ca）and phosphorus（P）were detected before and after six months of administration of alendronate combined with calcium agent.Results After six months of alendronate administration,the BMD of lumbar vertebrae（L₂～L₄）increased significantly（P< 0.01）,and the level of serum BGP,ALP and P decreased significantly（P<0.01）. Conclusion For the Chinese postmenopausal osteoporotic women,BMD of lumbar vertebrae improved and bone metabolic marker-BGP decreased after six months of alendronate administration.更多还原