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槲皮素抗菌活性的研究
Study on the Antibacterial Activity of Quercetin
【摘要】 以大肠杆菌、金黄色葡萄球菌等为实验菌株,采用药敏纸片法考察槲皮素的抗菌活性。槲皮素对金黄色葡萄球菌的抗菌效果最好,最低杀菌浓度小于0.0061μmol.mL-1;对胶质芽孢杆菌抗菌效果次之,最低抑菌浓度小于0.0061μmol.mL-1;对大肠杆菌、苏云金芽孢杆菌、枯草芽孢杆菌、铜绿假单胞菌也有较为明显的抗菌效果,最低抑菌浓度分别为0.0242μmol.mL-1、0.0061μmol.mL-1、0.0485μmol.mL-1、0.0121μmol.mL-1,最低杀菌浓度分别为1.5522μmol.mL-1、6.2086μmol.mL-1、3.1043μmol.mL-1、1.5522μmol.mL-1;对人仓白杆菌无抗菌效果。槲皮素具有广谱抗菌性,并且对革兰氏阴性菌的抗菌作用强于革兰氏阳性菌。
【Abstract】 The antibacterial activities of quercetin to bacteria,such as Escherichia coli,Staphylococcus aureus were preliminarily tested by Neo-Sensitab disk-diffusion method.The antibacterial activity to Staphylococcus aureas was the most remarkably,minimal bactericidal concentration(MBC) was less than 0.0061 μmol·mL-1.The antibacterial activity to Bacillus mucilaginosus was the secondly remarkably,minimal inhibitory concentration(MIC) was less than 0.0061 μmol·mL-1.Quercetin had obviously antibacterial activities to Escherichia coli,Bacillus thuringiensis,Bacillus subtilis,Pseudomonas aeruginosa,too.MIC was respectively 0.0242 μmol·mL-1,0.0061 μmol·mL-1,0.0242 μmol·mL-1,0.0121 μmol·mL-1.MBC was respectively 1.5522 μmol·mL-1,6.2086 μmol·mL-1,3.1043 μmol·mL-1,1.5522 μmol·mL-1.However,quercetin had no antibacterial activity to Ochrobactrum anthropi.Quercetin showed extensive antibacterial activity against Gram-negative bacteria and even more strongly than against Gram-positive bacteria.
【Key words】 quercetin; minimal inhibitory concentration; minimal bactericidal concentration;
- 【文献出处】 化学与生物工程 ,Chemistry & Bioengineering , 编辑部邮箱 ,2009年04期
- 【分类号】Q946
- 【被引频次】146
- 【下载频次】1566