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槲皮素抗菌活性的研究

Study on the Antibacterial Activity of Quercetin

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【作者】 秦晓蓉张铭金高绪娜林义马利何思宜

【Author】 QIN Xiao-rong1,ZHANG Ming-jin1,2,GAO Xu-na1,LIN Yi1,MA Li1,HE Si-yi1 (1.College of Chemical Engineering and Technology,Wuhan University of Science and Technology,Wuhan 430081,China;2.Wuhan Institute of Physics and Mathematics,The Chinese Academy of Sciences,Wuhan 430071,China)

【机构】 武汉科技大学化学工程与技术学院中国科学院武汉物理与数学研究所

【摘要】 以大肠杆菌、金黄色葡萄球菌等为实验菌株,采用药敏纸片法考察槲皮素的抗菌活性。槲皮素对金黄色葡萄球菌的抗菌效果最好,最低杀菌浓度小于0.0061μmol.mL-1;对胶质芽孢杆菌抗菌效果次之,最低抑菌浓度小于0.0061μmol.mL-1;对大肠杆菌、苏云金芽孢杆菌、枯草芽孢杆菌、铜绿假单胞菌也有较为明显的抗菌效果,最低抑菌浓度分别为0.0242μmol.mL-1、0.0061μmol.mL-1、0.0485μmol.mL-1、0.0121μmol.mL-1,最低杀菌浓度分别为1.5522μmol.mL-1、6.2086μmol.mL-1、3.1043μmol.mL-1、1.5522μmol.mL-1;对人仓白杆菌无抗菌效果。槲皮素具有广谱抗菌性,并且对革兰氏阴性菌的抗菌作用强于革兰氏阳性菌。

【Abstract】 The antibacterial activities of quercetin to bacteria,such as Escherichia coli,Staphylococcus aureus were preliminarily tested by Neo-Sensitab disk-diffusion method.The antibacterial activity to Staphylococcus aureas was the most remarkably,minimal bactericidal concentration(MBC) was less than 0.0061 μmol·mL-1.The antibacterial activity to Bacillus mucilaginosus was the secondly remarkably,minimal inhibitory concentration(MIC) was less than 0.0061 μmol·mL-1.Quercetin had obviously antibacterial activities to Escherichia coli,Bacillus thuringiensis,Bacillus subtilis,Pseudomonas aeruginosa,too.MIC was respectively 0.0242 μmol·mL-1,0.0061 μmol·mL-1,0.0242 μmol·mL-1,0.0121 μmol·mL-1.MBC was respectively 1.5522 μmol·mL-1,6.2086 μmol·mL-1,3.1043 μmol·mL-1,1.5522 μmol·mL-1.However,quercetin had no antibacterial activity to Ochrobactrum anthropi.Quercetin showed extensive antibacterial activity against Gram-negative bacteria and even more strongly than against Gram-positive bacteria.

  • 【文献出处】 化学与生物工程 ,Chemistry & Bioengineering , 编辑部邮箱 ,2009年04期
  • 【分类号】Q946
  • 【被引频次】146
  • 【下载频次】1566
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