【摘要】 以4-二甲氨基吡啶为催化剂,以维生素E和琥珀酸酐为原料合成维生素E琥珀酸酯。采用正交设计法对工艺进行优化,并采用HPLC法对产品进行了分析。研究了原料配比、催化剂用量、溶媒用量、反应温度、反应时间等因素对产率的影响及维生素E琥珀酸酯在不同贮藏条件下的稳定性。结果表明,在优化的条件下,维生素E琥珀酸酯的平均产率达88.57%;维生素E琥珀酸酯对光和热均不稳定,应在低温、避光条件下制备和保存。更多还原

【Abstract】 Catalyzed by 4-dimethylaminepyridine,vitamin E succinate was synthesized with vitamin E and succinic anhydride.Through orthogonal experiment,the optimum process was obtained,and the vitamin E succinate product was analyzed by HPLC.The influences of the reaction conditions on yield,such as stuff ratio,catalyst dosage,solvent dosage,reaction time and reaction temperature,and the storage stability of vitamin E succinate were investigated.The average yield of vitamin E succinate was 88.57% under optimum conditions.Vitamin E succinate was not stable for natural light and heat,so must be prepared or stored under low temperature and dark condition.更多还原