【摘要】 目的观察注射用酚妥拉明治疗小儿急性下呼吸道感染合并心衰的有效性和安全性。方法84例急性下呼吸道感染并心衰患儿随机分为治疗组和对照组,治疗组是在常规治疗?对照组?基础上加用酚妥拉明静脉滴注治疗,每次剂量0.3-0.5mg/(kg.次),每天2-3次,连续使用3-7d。观察两组治疗后发热、咳嗽、喘息等临床症状及肺部阳性体征消失时间、心功能改善情况。结果治疗组发热、咳嗽、喘息等症状和肺部阳性体征消失时间及心功能恢复正常时间均明显短于对照组(P(0.05),两组临床疗效比较差异具有统计学意义(P(0.05)。结论常规标准剂量下应用酚妥拉明静脉滴注治疗小儿急性下呼吸道感染合并心衰的疗效好,安全性高,值得临床借鉴使用。更多还原

【Abstract】 Objective To observe the efficacy and safety of phentolamine in the treatment of children with acute lower respiratory tract infection and heart failure. Methods 84 children with acute lower respiratory tract infection and heart failure were randomly divided into treatment group and control group. Control group was treated with conventional therapy,and treatment group was managed with intravenous phentolamine based on the conventional therapy. Phentolamine was employed with the dose of 0.3-0.5 mg /kg once,2 or 3 times a day,for 3 -7 days. The disappearance time of fever,cough,wheezing and other clinical symptoms as well as pulmonary positive signs were observed after treatment. Additionally,cardiac function was evaluated. Results The disappearance time of clinical symptoms and pulmonary positive signs and the time of cardiac function returned to be normal in the treatment group were significantly shorter than those in the control group (P<0.05). Conclusion It is effective and safe to employ conventional dose intravenous phentolamine in the treatment of children with acute lower respiratory tract infection and heart failure.更多还原