【摘要】 目的:探讨低(无)应答人群复种重组酵母乙肝疫苗的有效方法。方法:乙肝疫苗低(无)应答对象208例,随机接受2种复种方案,A组105例,予乙肝疫苗30μg1次接种;B组103例,予乙肝疫苗10μg按0、1、6月免疫程序接种,分别于首次接种后1个月、2个月、7个月检测抗-HBs。结果:复种后1个月和2个月,A组抗-HBs阳性率分别为53.33%(56/105)和60.95%(64/105),B组分别为9.71%(10/103)和22.33%(23/103),A组的1月和2月抗-HBs阳性率均高于B组(X~2=45.679,31.876,P=0.000);复种后7个月抗-HBs阳性率,A组55.24%(58/105)和B组46.60%(45/103)比较,差异无统计学意义(X~2=1.552,P=0.213)。B组随接种次数增加及时间延长,抗-HBs阳性率逐渐增加,不同时间抗HBs阳性率差异有统计学意义(X~2为6.098～30.385,P均<0.05)。结论:低(无)应答人群复种乙肝疫苗时,增加单次剂量可提高免疫应答,并减少接种次数。更多还原

【Abstract】 Objective:To investigate effective projects for revaccination among people of non-and-hyporesponders to hepatitis B vaccine.Methods:People of non-and-hyporesponders to hepatitis B vaccine were randomly given two different projects for revaccination.105 people of group A were given hepatitis B vaccine 30μg just once.103 people of group B were given hepatitis B vaccine 10μg each time according to the immune procedure in 0,1st,6th month.The anti-HBs in blood were tested in 1 st,2nd,7th month after the first injection.Results:In 1 st and 2nd month after the first injection,the anti-HBs positive conversion rate of group A were 53.33%(56/105) and 60.95%(64/105), respectively,while that of group B were 9.71%(10/103) and 22.33%(23/103),respectively.The anti-HBs positive conversion rate of group A in 1st month(X~2=45.679,P=0.000) and 2nd month(X~2=31.876,P=0.000) were higher than that of group B,respectively.There was no significant difference(X~2=1.552,P=0.213) between the anti-HBs positive conversion rate of group A(55.24%,58/105) and that of group B(46.60%,45/103) in 7th month after the first injection.With the increase of vaccination times and extention of time,the anti-HBs positive conversion rate of group B increased gradully,there were significant difference among conversion rates of 1th,2nd,7th month in grorp B (X~2=6.098～30.385,P<0.05).Conclusion:The single increasing dose of hepatitis B vaccine may strengthen immune response and decrease vaccination times when people of non-and-hyporesponders were revaccinated to hepatitis B vaccine.更多还原