【摘要】 目的:探讨血运重建对急性心肌梗死(AMI)患者心室重塑和心功能的影响。方法:将65例AMI患者分为两组,常规强化内科保守治疗组(A组,n=20)和在此基础上的血运重建治疗组(B组,n=45),20例正常人为对照组(C组);应用超声心动图观察两组AMI后1周、3月及6月时左室舒张末期内径(LVEDD)、左室收缩末期内径(LVESD)、左室舒张末期容积(LVEDV)、左室收缩末期容积(LVESV)、左室射血分数(LVEF)及二尖瓣血流舒张早期流速与心房收缩期流速的比值(VE/VA)。。结果:A组和B组各时点的LVEDD、LVESD、LVEDV及LVESV均大于C组(P<0.05),LVEF和VE/VA均小于C组(P<0.05);B组6月时LVEDD、LVEDV、LVESV及3月和6月时LVESD较A组相应时点显著降低(P<0.05),而B组6月时LVEF较A组显著升高(P<0.05),A组和B组同时点间的VE/VA比较无统计学差异(P>0.05)。结论:AMI患者出现明显左室重塑和心脏收缩、舒张功能减退,血运重建可有效恢复冠状动脉前向血流,抑制AMI后中期心室重塑,并改善左室收缩功能。更多还原

【Abstract】 Objective: To evaluate the effects of revascularization on ventricular remodeling and cardiac function in patients with acute myocardial infarction(AMI).Methods: Sixty-five AMI patients were divided into 2 groups: conventional therapy group(group A,n=20) and revascularization group(group B,n=45).Twenty healthy persons served as normal control(group C,n=20).The left ventricular end-diastolic dimension and volume(LVEDD and LVEDV),left ventricular end-systolic dimension and volume(LVESD and LVESV),left ventricular ejection fraction(LVEF),ratio of early and late diastolic blood flow peak velocity(VE/VA) of the 3 groups were determined by echocardiography at the 1st week,the 3rd month and the 6th month after AMI.Results: In groups A and B,LVEDD,LVEDV,LVESD and LVESV were higher,LVEF and VE/VA were lower in all time frames than those in group C(P<0.05).The LVEDD,LVEDV and LVESV at the 6th month after AMI,and LVESD at the 3rd and the 6th month were lower,while the LVEF on the 6th month was higher in group B than those in group A.There was no significant difference of VE/VA between group A and group B in any time frame.Conclusions: AMI leads to ventricular remodeling and cardiac dysfunction.Revascularization may inhibit ventricular remodeling and improve left ventricular systolic function in AMI patients.更多还原