【摘要】 目的:探讨反复呼吸道感染(RRTI)与免疫球蛋白、IgG亚类的关系,为治疗RRTI提供理论依据。方法:采用免疫散射比浊法,检测28例RRTI患儿IgG、IgA、IgM及IgG亚类水平并与对照组比较。结果:RRTI患儿血清IgG、IgA水平与对照组相比差异无显著性,血清IgM水平与对照组相比明显降低(t=-2.524,P<0.05);RRTI组血清IgG2和IgG4水平比对照组明显降低(t=-2.107,-2.72;P<0.05或P<0.01)。结论:RRTI患儿存在一定程度的免疫功能紊乱,检测血清总免疫球蛋白和IgG亚类可提高RRTI的诊断率。更多还原

【Abstract】 Objective:To explore the relation of recurrent respiratory tract infection(RRTI) with serum levels of immunoglobulin and IgG subclasses,and to provide theorical basis for RRTI treatment.Methods: Serum levels of IgG,IgA,IgM and IgG subclasses of 28 RRTI(18 males and 10 females) children and 15 normal children(5 males and 10 females) were determined with immuno-scattered turbidity method,and the data were analyzed.Results: There was no significant difference of levels of IgG and IgA between RRTI group and control group(P>0.05);Serum level of IgM of RRTI group was significantly lower than that of control group(P<0.05);Serum levels of IgG2 and IgG4 in RRTI group were significantly lower than those of control group(P<0.05,P<0.01).Conclusion: there is immune disorder to some degree in children with RRTI.To detect serum levels of immunoglobulin and IgG subclasses in children with RRTI could increase correct diagnosis rate.更多还原