【摘要】 目的探讨职业性铅暴露对工人血脂质过氧化及抗氧化酶的影响。方法选择广西某冶炼厂53名铅作业工人为暴露组,不接触铅烟尘及其他有害物质的志愿者66名为对照组,测定血铅(BPb)、血清丙二醛(MDA)含量及超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)活力。结果作业场所空气中铅烟平均浓度为0.43 mg/m3(0.05~1.65 mg/m3),铅尘平均浓度为0.44 mg/m3(0.02~1.15 mg/m3),均超过时间加权平均容许浓度。暴露组BPb含量高于对照组,400μg/L≤BPb<600μg/L组血清SOD活力高于BPb<200μg/L组,BPb≥600μg/L组血清SOD活力低于其他各组,BPb≥600μg/L组血清GSH-Px活力低于400μg/L≤BPb<600μg/L组,差异均有统计学意义(P<0.05或P<0.01)。结论400μg/L≤BPb<600μg/L时,可引起血清SOD活力增高;BPb≥600μg/L时则引起血清SOD、GSH-Px活力明显降低,提示,铅有自由基毒性。更多还原

【Abstract】 Objective To study the effects of lead fume and dust exposure on lipid peroxidation and antioxidant enzymes in blood.Methods 53 lead exposed workers from a smeltery in Guangxi were taken as the exposure group;and 66 volunteers unexposed to lead and other hazardous materials were taken as the control group.The contents of blood lead(BPb)and MDA,the activities of SOD and GSH-Px in serum were measured.Results The average concentrations of Pb fume and dust in the air of workplaces were 0.43 mg/m3(0.05~1.65 mg/m3) and 0.44 mg/m3(0.02~1.15 mg/m3)respectively,all of which exceeded TWA concentration.The content of BPb in the exposed group was significantly higher than that of the control group.The activity of SOD in serum of 400 μg/L≤BPb<600 μg/L subgroup was significantly higher than that of BPb<200 μg/L subgroup,but the activities of SOD and GSH-Px in serum of BPb≥600 μg/L subgroup were significantly lower than those of other groups.The activity of GSH-Px in serum of BPb≥600 μg/L subgroup was significantly lower than that of 400 μg/L≤BPb<600 μg/L subgroup.Conclusions When the concentration of BPb achieved 400～600 μg/L,it could increase the activity of SOD in serum.When the concentration of BPb was≥600 μg/L,the activities of SOD and GSH-Px in serum lowered obviously.It indicates that Pb becomes toxic to free radical.更多还原