【摘要】 目的探讨2型糖尿病患者血清γ-谷氨酰转移酶(GGT)的变化,分析GGT与血脂指标的关系。方法对560例2型糖尿病患者测定血清GGT、空腹血糖、总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)。根据GGT测定值分为4级,即Ⅰ级小于18 U/L;Ⅱ级18～25 U/L;Ⅲ级26～39 U/L;Ⅳ级大于或等于40 U/L,分析与血脂的关系。结果560例中GGT升高者136例,异常率为24.28%,男性患者GGT异常率为26.52%,女性患者异常率为21.46%,男女患者间GGT异常率差异无统计学意义(t=1.64,P>0.05)。糖尿病患者GGT升高的特点,多数为轻度升高,约1/4的患者GGT升高超正常值两倍以上。GGT升高组TG水平[(2.85±3.26)mmol/L]明显高于GGT正常组[(1.85±1.56)mmol/L],差异有统计学意义(t=4.824,P<0.001)。分级分析表明,男性和女性患者血清TG水平均随GGT升高而增高,不同组间TG水平差异有统计学意义(F=5.891、7.721,P<0.001)。相关分析,GGT水平与TG水平呈正相关(r=0.231 8,P<0.01),而其他血脂项目,不同GGT水平组间差异无统计学意义(P均>0.05)。结论2型糖尿病患者伴血清GGT升高者较多见,GGT与TG密切相关,TG水平随GGT升高而增高,两者呈平行关系。GGT和TG的增高可能均为糖尿病的危险因素。更多还原

【Abstract】 Objective To investigate the change of serum gamma-glutamyltransferase(GGT)in type 2 diabetic patients and its relationship with blood lipids.Methods Serum GGT,fasting blood glucose, total cholesterol(TC),triglyceride(TG),high density lipoprotein cholesterol(HDL-C),and low density lipoprotein cholesterol(LDL-C)were determined in 560 patients with type 2 diabetic.The results of GGT were classified into four grades:gradeⅠ:GGT<18 U/L;gradeⅡ:GGT 18-25 U/L; gradeⅢ:GGT 26-39 U/L;gradeⅣ:GGT≥40 U/L.The relationship of GGT with blood lipids was analyzed.Results Of the 560 patients,136(24.28%)had increased GGT.The rate of abnormal GGT was 26.52%in males and 21.46%in females(t=1.64,P>0.05).Most diabetic patients had mildly increased GGT,and approximately 1/4 patients had a GGT level two times higher than the normal GGT level.The TG level was significantly higher in the increased GGT group[(2.85±3.26)mmol/ L]than the normal GGT group[(1.85±1.56)mmol/L](t=4.824,P<0.001).Analyses based on the GGT grades demonstrated that the serum TG level increased with GGT in both male and female patients,and differed significantly between the GGT grades(F=5.891,7.721,P<0.001);correlation analysis showed a positive correlation between GGT and TG(r=0.231 8,P<0.01).There were no statistical difference between GGT and the other blood lipid parameters in different GGT level groups (P>0.05).Conclusion Serum GGT increase is common in type 2 diabetic patients and the GGT level is closely related to the TG level.The TG level increases with the GGT level.Increased GGT and TG may be risk factors for diabetes mellitus.更多还原