【摘要】 目的:比较4种抗生素临床治疗宫颈沙眼衣原体感染的疗效。方法:258例生殖道沙眼衣原体感染患者按就诊号分为4治疗组,莫西沙星组(n=63);克拉霉素组(n=63);阿奇霉素组(n=65);米诺环素组(n=67)。分别于治疗结束后的第21天和第60天行宫颈拭子沙眼衣原体检测,根据实验室检查结果判断疗效。结果:4组微生物学转阴率分别为88.89%,71.43%,75.38%和86.57%;莫西沙星组与克拉霉素和阿奇霉素组在转阴率上差异有统计学意义(P<0.05)。第60天检测复发率分别为3.7%,8.9%,4.1%和3.5%,各组间无统计学意义。结论:4种抗生素对沙眼衣原体感染均有效,莫西沙星和米诺环素治疗沙眼衣原体生殖道感染疗效较好,本结果为临床选择用药提供了一定的实验依据。更多还原

【Abstract】 Objective:To compare the clinical effects of four antibiotics in the treatment of cervical chlamydia trachomatis infection. Methods:258 patients with genital tract chlamydia trachomatis infections were divided into 4 groups according to their registration numbers which were the moxifloxacin group (n =63),the clarithromycin group (n =63),the azithromycin group (n =65) and the minocycline group (n =67). Chlamydia trachomatis detections by cervical swabs were performed at the 21th and 60th day after the end of medication. And clinical effects were evaluated according to the results of laboratory examinations. Results:The negative-turning rates of microbiology in the 4 groups were 88.89% ,71.43% ,75.38% and 86.57% ,respectively. Statistical significance was showed in the differences of negative-turning rates between the moxifloxacin group and the clarithromycin as well as azithromycin group (P<0.05). Recurrence rates at the 60th day were respectively 3.7%,8.9%,4.1% and 3.5%,with no significant differences among the 4 groups. Conclusions:These 4 antibiotics are all effective on chlamydia trachomatis infections. Moxifloxacin and minocycline are relatively superior for the treatment of genital tract chlamydia trachomatis infections. The results of our experiment will provide some evidences for clinical drug choices.更多还原